SARS-Cov-2 has upended every aspect of public life and is a medical and economical challenge of global scope. The COVID-19 pandemic is taking a toll on day-to-day life, on people’s health, on businesses, on the domestic economy and on global trade. The current situation throughout Germany and across the world is posing major challenges for people. Working at the forefront of the fight against the pandemic, Fraunhofer experts are supporting the efforts of industry and society to cope with the immediate effects and the consequences to come: from acute projects in the life sciences sector to close cooperation with companies to immediate medical and medical-technical support.