Sensors, Volume 17, Issue 9 (September 2017)Cover Story Sensing principle of dual-mode electro-optical biosensors based on evanescent wave detection. The properties of the optical mode confined in a both photonic and electrochemical compatible substrate are sensitive to the overlap between the evanescent field and the surrounding environment. A change in the local refractive index, for example due to the formation of an antibody-antigen (i.e. bioreceptor-target molecule) complex, leads to a change in the properties of the confined optical mode and to a quantifiable readout of molecular binding. These changes can also be detected, and in some cases directed, through electrochemical interrogation, which provides parallel, uncorrelated information about molecular binding to provide deeper insight into biomolecular interactions.
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